I don't own a 22/250 but I use 8208XBR in both a .223 and a .308.
In the .223, excellent results from 40 grain up to 75 grain bullets.
The .308 likes it from 110 to 168 grain bullets.
It is a stable, consistent, and all around good powder for both calibers.
A little too fast burning for heavy bullets, but great for light to medium weight bullets.
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