I have two Savage single shot bolt action varmints. One is an early model 112J in 25-06 that will put 75 gr hornady hp's in the same hole all day long. The other is a 223 AI with a 1 in 14" twist barrel. It basically shoots 40 grainers like the 22-250 shoots 55 grainers but you would not be at any disadvantage with a 204 or 22-250.