Ever deer I shot with my 14" 375JDJ no matter the placement it was one shot and down, I have only used 220's, I had one deer that I couldn't get a good shot at its vital area so I figured if I put a round through its hips it would be down then I could get a kill shot, the shot was only around 80-85 yards and by the time I got to the deer it was dead. I guess dumping all that energy was just too much I did lose about 4-5 lbs. of meat.

The only other caliber that comes close to the 375 is the 460 S&W even with 200 grain loads it is just awesome.