With your .308 having a bolt face .Dia of .470" you can change to these calibers and many in between with nothing more than a new barrel:
225 Winchester
22/250 Remington
6mm Creedmoor
6mm Norma BR
243 Winchester
250 Savage
260 Remington
6.5 Creedmoor
6.5/284 Norma
7/08 Remington
284 Winchester
300 Savage
308 Winchester
338 Federal
35 Remington
358 Winchester
The 12FV internal magazine is nothing more than the guts of a standard external magazine with the baseplate removed. So if you wanted to change to say, .223, just buy a mag and swap it out.
There is really no universal caliber...have to match your needs and expectations. But 6.5 Creed seems to be the darling these days.
My 12FV in .308 shoots 1/2" groups with 168gr Federal GMM...they can be amazingly accurate.
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