I've loaded for, shot and hunted pretty much the whole range from 22 Hornet to 470 Nitro and 450 Dakota.

Excluding dangerous game (ie MOST hunting in the lower 48) I have to say 308 or any 30 cal from 308 to 300 Wby.

As soon as you start adding in stuff that can kill you without thinking about it, the answer has to change!

That's probably why there are three 308s in my safe (along with a 300 H&H, a 30-40 Krag, a 30-30 and a 300 Blackout...I guess I like 30 cal).