I Think Walgreens has Advil on sale.

20-25 yards should tell you what you need to know.
For home defense purposes there are lots of loads that are adequate and then some.
Ever since I saw what a 3" 2oz load of copper plated #4s through an extra full choke do to a hog while turkey hunting at about that distance I have kept some on hand. I have no doubt that a good duck load or #4 buck would also be more than adequate for most "self defense" distances