There's no reason it wouldn't work. I think that, depending on which model of axis you have, you may have a baffle on the bolt-head to shorten the throw. If you have the baffle, you likely wouldn't have enough rearward movement on your bolt to eject or chamber the round. But even that is as simple as snagging a bolt head without the baffle (if you even have one in the first place. Do you already have an Axis, or are you looking to snag one just for this project?