I will provide my opinion, for what it is worth, which is nothing. I would opt for the 7mm-08 just because it can shoot a bigger bullet, which can't hurt for hunting. I don't own a 7mm-08 though, so no firsthand experience. I have a 6.5 Creedmoor target rifle, but don't hunt. If you were target shooting I would recommend the Creedmoor. I would opt for .308 personally, but you did not ask about it. Creedmoor would work though. I used to shoot deer with a .243 and it always killed them.