They have different shoulder angles. Not compatible. 250 Sav 26.5 degree, 22-250 is 28 degree.
Only in cases where the datum diameter and shoulder angle are the same can gauges be used across several cartridges, such as 20 Practical/223/6x45, 25-06/30-06, 243/308 etc.
When in doubt look at the SAAMI drawings available at www.saami.org.
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