Given the fact that you are going to Alaska with the possibility of running into critters bigger and meaner than you intend on hunting I would take the .280AI with the ability to dump as much energy as possible if needed. I would also look into shooting something along the lines of a 168 class bullet and practice out to 600 yards at a minimum. Your 150 will probably work fine but the extra energy, less wind drift and the possibilty of a longer than average shot makes a good argument for a heavier bullet.
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