Go with the 10" twist. That way you won't be limiting your bullet selection.
The faster twist won't over-spin the lighter bullets.
Andrew is right on the money with the simplicity of the 338/375 Ruger. It's very close to the Sin dimensions. The Sin is based on the Ultramag case, just a bit fatter than the 375 Ruger.
The new line of Nosler's are almost identical to what Devin did with the Sin's.
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