22 BR is a sweet cartridge, very accurate, very easy to load for.

If you go 22-250 in a custom barrel, go AI. 22-250 brass grows very fast and I hate trimming cases. I have both.

22-250 (thin factory barrel) shooting 52 gr Sierra HPBT match 1410's that is deadly on prairie dogs. These 1410's are very accurate and expand even at 223 velocities out to 600 yards. Not all match bullets expand, but these do. I also carry a couple of rounds loaded with Sierra 65 gr GameKings in case I see a pig or other large varmint when I am walking around.

22-250 AI shooting 75 gr A-max.

Keith