I dont think there is a single set answer to that question.
I also think it varies depending on a particular cartridge.
For example, one of my guns is a large 338 in which the powder charge
will be from about 130 gr to about 140 gr. There are only 3 or 4 current powders
that can be used and theres little difference in any of them. There is only 1
primer, that being the fed 215 because its the hottest of all available primers.
And even that isnt always hot enough. So that leaves very few bullets and seating depth
as the major issues for accuracy with that cartridge. Larger cartridges are even more limited as for components.