First off dont go pulling any bullets on your existing 22 250s. Just shoot them in the new chamber and their good to go.
Then resize with your new ai dies. Neck turning as a rule isnt necessary in factory chambers. Fact is you can ruin brass
by turning them for factory chambers if your not very carefull. As for your loading process, if (your) satisfied with how your guns shoot,
then behappy with the way you currently load. If you are or intend becoming a serious competetive shooter, then each thing you do
could affect your scores. But even then, the order of priorities would be a gun worthy of the extra effort spent loading.
If you and your guns are capable of inch or better groups consistantly, then your good to go even for long range shooting.
That would equal out to about 10 inches at 1000. Fact is most guys here including me cant shoot that good on a consistant basis.