IMHO I believe that 165-180 grain bullets in the 300 Win Mag and 140 grain bullets in a 264 Win Mag will take anything on the North American Continent.
I would, however, prefer an A-10 mounted Vulcan for large brown bears.
uj
P.S. The Swedes have been killing moose with the 6.5 x 55 for 100 years and they have never thought to ask if it was enough gun.
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