I used 142 SMKs and shot at a wheel rotor at 600yds and it penetrated cleanly thru on every hit with authority. The rotor is 3/8" thick on the outside and 1/4" thick on the inner. So I think it won't have any problems penetrating bones and hides.

btw, I also shot at the rotor with a 243 using 87grns vmax and it only dented the rotor. So I don't recommend using a 243. ;D