Doon. Welcome to the forum. Nice rifle and both are great calibers.
What is the intended purpose? Their number 3 contour would make for a good walking rifle, particularly if you cut it down to 20".
I don't have any experience with the Grendel but am a big fan of the 260 Rem as a long range caliber. I have Shilen's 24" number 5 contour on my long range rifle. It isn't light, but does what it needs to do from the bench at 1000 yards.
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