The benefits far out weigh any negatives. I have built several Ackley cartridges and have never had an issue. The very rare case trimming is a big bonus but my favorite thing about them is the efficiency. There may be other factory chamberings out there that provide the same performance but the Ackley's have always given me better performance with less powder. My 260 Ackley for example does anything a 6.5-284 will do and my 6.5-06 Ackley will do anything the 264 win mag will do. The only difference is I am using significantly less powder to do it. Which translates into better barrel ware and less recoil.