Yikes we have a mess of a thread here.
We need a lot more info, and a lot more very specific wording from you.

You have been loose with descriptions and phrases. Does EVERYTHING(factory also) you've shot keyhole, or only the bulk of your reloads? Do things keyhole, or is it a fine deer killer? You've said both.

Twist rate means absolutely nothing without velocity. Not sure what book told you to use that powder, but it is VERY fast for a 160 class bullet. What is your velocity, not what a book told you, YOUR velocity? That will answer whether or not the keyhole issue is due to stabilization, or bore issues. What specific factory ammo have you shot? Weights, amounts, brands?

The most important things haven't gotten asked above your specific load troubles, is your equipment. What is the status of your trigger? Weight, creep, let-off, consistency? Is your barrel floated? Is the stock properly secured, what is the quality and state of your optics and mounts?
If absolutely NO ammo, factory or otherwise works; something else is going on. You say this has been for a year now, surely you haven't tolerated an abysmal rifle and not double checked any of these things in that amount of time?

Love to help, but need some more specific info first :)