Varget is my go to for anything based on the 22-250 or 308 family of cases. My 22-250 loves Varget and 55gr Sierra's or V-Max's. Haven't had any issues stabilizing them in the 12 twist I used to have (was a 12FV) or the 14 twist I have now.

Sorry I can't speak for the Varmageddon bullets specifically but I think you will be fine. As said above I'd too go with the 2.495" and start working up your charges til you find the potential sweet spot and then start playing with your depth.