Thanks for the responses gentlemen. I knew it wouldn't be exact same POI, but I didn't expect it to be completely off the target at 100 yards. I have already put indexing marks on the 308 setup. Will do the same once I zero the 22-250. I will also keep log book to record relative scope changes from one caliber to the other. I know I will still have to rezero every time I swap barrels but I don't mind having an excuse to send a few rounds down the range. I want to add a 6.5 CM to finish off my setup. I would do a 6.5x55 Swede, but I am running a short action and I don't think the Swede is possible in a short action