I thought about just sticking with the 270 for coyote hunting but I love a project and having multiple calibers on one frame is exciting. I wanted the 22-250 bad but availability of factory ammo has me a little leery but I'm trying to find a used reloading press now because I also have 300 savage model 99 takedown that is also tough finding ammo for so if I start reloading I can buy dies and then it opens up all kind of possibilities. Right now for the 110 build it's probably down to either 22-250 or 243....I've had a couple .223 mini 14's and wasn't to impressed with those. I was thinking 204 ruger but nobody seems to prefer that caliber for coyotes so I'll listen to the ones that do a ton more shooting than I get to.