I would not use thread locker on anything gun related personaly, but I have never had something mounted that I was not going to remove at some point and time.
Sounds like you understand the importance of secure scope instalation so ... some things I would look into are; Ammo, trigger pull, floated barrel and tang and possibly issues with bedding.
Do you know the twist rate for that barrel? It should be an 8. I believe the better weight bullets are 129 to 142 gn's. So what are you shooting?
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