I think the 80 or 85 grain TSX or TTSX in the .243 will put down ANY whitetail or mule deer in America with extreme prejudice. They really are bad news! I currently have loads worked up with TTSX's for almost all of my rifles, and I am working on the others this summer. I have a couple that are being picky with the groups, but I will get them ironed out. I shot a couple of deer with the 120 grain TTSX in .260 this past season, my daughter shot one with a .243 the 80 grainer with only a 60% low recoil load, and my nephew shot a buck with one in 7mm08. All of them performed very well and the deer all died very quickly if not DRT.