For me personally the .223 was my choice. Everything I'll be shooting at will be at 300 yards and less. The .223 can do everything the .22-250 can do out to at least 250 yards. For me shooting anything below 300 yards, you are just burning more powder with the .22-250. Now if you live where you can stretch your yardage way out there, then a .22-250, or even a .243 win starts making more sense.

As far as reloading, I do reload and I can still reload .223 cheaper than I can .22-250. The bullet selection is exactly the same, and the brass and powder are cheaper. The brass is less expensive for the .223, and you use less powder per load. Just my humble opinion.