I have shot a lot of 125 to 200 lb hogs. I would stick with the deer rifle for the hogs at that distance. Hogs are tough critters and hard on bullets so use a premium bonded or Partition type deer bullet for those longer shots.
A well placed shot with a 22-250 on the yote should be effective but I have no experience on yotes at that longer distance. I have shot several at 150 yds with a 223 and had no problems. Another 400 fps with the 22-250 over the 223 should allow you to stretch that distance a bit. Remember that a heart / lung shot on a yote is the shoulder, not behind it like on a deer.
Have fun with them varmints!
Keith
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