Maybe I have been lucky but I love my 204 for yote work. I've killed 50-60 yotes with mine and the vast majority of those plopped at the shot. I've shot several over 400 yards that required 1 shot only. One of the benefits to the 204 is how it treats pelts. If you call in a bobcat or a fox, a well-placed shot won't destroy the fur. I exclusively use the 39 gr sierra blitzking but the 40 vmax and 45 gr hornady bullets will kill them just the same. One of my favorites has been the straight chest shot, shots to the sternum just buckle 'em with zero hide damage.

The 22-250 has and always will be a yote killing machine, can't go wrong there.