I was taught the crease shot and try to do that but on a large buck I'll take the high shoulder shot. I've had 3 deer shot there with my .243 and they are all DRT and hitting the shoulders and spine creates a lot of shrapnel. My first big buck I shot when I was 12 and though I hit the shoulder and spine (4-6 inches gone) it's lungs had been pretty messed up by bone.