Welcome to the never ending school of precision reloading!
Fireform the brass, then start the worry process!
There is a LOT more to it than just having straight cases.
Less run out is always better in theory. Run out is something that is a constant fight to control. You must also have a chamber that can take advantage of a properly concentric round or you're wasting time even doing it.
If the chamber isn't concentric the bullets will never get a straight start into the rifling. Measure a few rounds that have been fired and that will tell you something about the chamber. The chamber also must be in perfect alignment with the bore, or you're wasting time again. A bore scope will tell you this.
Many people do not use the ejector pin in the bolt head of a Savage rifle for targets because of the concentric issue. We pluck the brass from the bolt head after shooting. The pin will force the brass out of alignment in the chamber.
The brass must also be sized properly and the dies need to match the chamber as closely as possible. There are different methods of mounting the dies in the press that can help or hinder run out.
Bullet seating has a LOT to do with run out also. A die that supports at least the neck (Hornady dies) of the brass is always better. Supporting the entire case works well too such as with the Wilson dies.
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