Actually... for me, Varget behind the B185 Juggernaut worked better in a barrel that had some serious mileage on it and a much longer throat. There I was able get 44+ gn behind the bullet without excess pressure and get up to 2730-2740fps - until the barrel finally crapped out. With a 'new' barrel and the standard 12 F/TR chamber/throat, I can only get 42 and change in there... and maybe 2640fps.

Same barrel, same seating depth, and 46.5gn of 2000MR gets me 2796fps, with zero pressure signs.

Accuracy is always king... but all else being equal, velocity helps a lot on the bad days