MOA,

Along with that, please remember that advertised claims and reality aren't always the same thing.
If you go to Hodgdon's website and look over the "tests" comparing how magical their extreme properties are, you will see several things.
1) Absolutely no relevant testing info is given(number of shots, SD, time in chamber, etc)
2) That RELATIVELY speaking, there is NOT much difference, and in the case of the 22-250, No tangible difference.

In the 22-250, the Extreme powder beat its next competitor by 6 fps. Regardless of sample size, that is not statistically a difference. The next in that line is only 16 fps off. How often are your ES numbers in the single digits with standard loads anyway??