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To start H380 powder was designed for the 22/250 the reason why it is called h380 is the developer thought the perfet load was 38.0 gr os it with a 52 gr bullet. According to Hodgdon 41gr is a max load with a 55gr SP. If your getting a sticky bolt opening then you need to back off that is a major presure sign. You have to remember with load data, it is subjective, they only way to be sure of anything is you need to match the load exactly, same brass, same bullet, same primer and so on. (And this would be great in a perfect world.) Your cases may have more or less capaisity that what the cases used in the manuals, also bullets designs can change pressures, and some lots of powder are hotter than others, and thats not considering the outside heat as well. Morel of the story is just beacuse a load is listed in a manual doesn't mean you can go to it. All load should be started out on the mid to light side of thing, and worked up with caution. When you see pressure signs such as a sticky bolt, ejector marks in the back of cases, shinny necks, back off, these are a signs of over pressure. A 22/250 is good about hinding overpressure signs to start with.
When using H380 I sujest using a magnum primer because it is harder to light ball powders. Honestly I have never gotten H380 to ever shoot great in a 22/250, it has been one of them powders that has plaqed me. I have found it is SOOOOOOOO much easier to tun 4895 in a 22/250. I have also never had good luck with ANY 55 gr bullet. I would say try some 52gr bullets When neck sizing brass after about 3 firings it will need to be body or full length sized. I have also found that when neck sizing brass you will get an extraction click after about 10 firings. When brass develops this click it is almost impossible to get ride of it, and it is time to throw it away.
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