There was a group of guys on here who mounted their scopes really high and made a stock that allowed for the barrel to be removed and then a new one placed, allowing them to go to the range and switch barrels through out the day. All barrels having the head spaced marked and all that, ill try to find the thread where they had pics and all the info.
But if you are just re-barreling and not using it as a switch gun then yes take the scope off, that's probably the easiest part of the whole thing...