How do you balance the multitude of variables that can be adjusted in reloading? Is there an order of operation in refining a load? Does changing one directly affect any of the others? I have identified the following variables, am I missing any? How important are they relative to each other? I'm just getting back into reloading after about 20 years off, and I wasn't very sophisticated back then.

powder choice
powder charge
primer choice
case overall length
neck tension
seating depth
bullet weight
bullet design

Thanks for the input.

Ron