i own a 25/06 and its a fine cartridge.
to use that exclusivly for prairie dogs would be like repairing a car with an adjustable wrench.
id rather use the right wrench for a given situation.
given a choice ill use the 223 w/50s the 22/250 ai w/60s the 6x284 w 105s and the 6.5 wsm w 140s.
in that order. but thats just me.