It will do very well with a good barrel, but extraction could in theory be a problem. The .35 Rem case head is ~0.013" smaller than the standard '06 head size but it will probably work just fine with the Savage bolt face. You can heat up .35 Remington loads quite a bit in a bolt action, an article in Handloader #98 gave load results for a 22" Remington M760 as follows:
Bullet - fps/fpe
150 FN - 2543/2155
180 FN - 2420/2342
200 RN - 2395/2548
250 RN - 2061/2359
Not quite .358 WCF performance, but well above factory specs. To me the biggest advantage would be improved accuracy over most lever actions....except for those 1/2 moa Marlins a few shooters like to brag on. ::)
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