It's better to shoot for the moon and hit the fencepost than to shoot for the fencepost and hit the ground!
I switch barrels but always back and forth between the same barrel/frame. I carefully measure the barrel to frame distance because that is part of headspace. IMHO if you change the headspace the POI and accuracy will change. Luckily I have 2 Contender and 2 Encore frames the measure .001 with most barrels. One other Contender measures .005 but shoots fine with a dedicated barrel. I do not know if the hinge pin hole in the frame or the barrel lug is drilled wrong.
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