Not counting AR-15s and 10-22s, I have not done any barrel changes yet. But, that sounds like a bunch of hassle for little return. I agree with Racer. I think there are some better options. I would at least find another receiver for each barrel. You can use quick detach mounts to swap the scope if you want to.

I would hate to mess with headspace and all the other tweaks over and over again just to have a rifle shoot at its best. You will have to shoot extra ammo too. In the end, I think you will find it is easier to just have separate rifles, scope and all.