A few things for you to mull over.
The default response needs to be: All rifles are like women, while potentially similar they are all different. Find out what yours likes, don't expect others to have this answer for you.

Your question about that powder. If you are choosing that because of the touted "Extreme" properties, you may be setting yourself up for a let-down. Powder insensitivity is NOT a universal property, it is such only under specific conditions. As an example: With 55gr bullets in the 223, Varget affords some fine accuracy. However compared to the very old ball powder H335, it is very temp sensitive; Dr. Bramwell has done many tests showing this.
Varget was designed for standard ball ammo in the 308(145-149gr). Personally, using 175 SMK's I didn't care for the results with Varget in my rifle. For me Win 748 or CFE provides the accuracy I desired.

Cheers