How many shots before you wear out a barrel also has a lot to do with how many shots you take in a string. For hunting rifles, it will be very tough to wear out a barrel to a point where it wouldn't be ethical to hunt with.
The 7mm magnum type cartridges will take down most animals that walk this planet. I wouldn't take it against the largest game, but will easily suffice for anything in North America. Make sure to use a quality hunting bullet, and you won't run into problems.
I would question the range that you plan on hunting. If the range is inside 500 yards, I would look at the 6.5mm rounds, specifically the 260 remington or the 6.5 creedmore.
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