Its all in how youre planning to use it. I would use 2 different rifles myself. Ive got a 22-250 (1-12 I think) I use it for 400+ yard shots. My 17 hornet I use for closer stuff....275-300yds. Im building a fast twist 6mm cartridge to really stretch out. I just prefer different cartridges, something different.
It would be simpler to go with 1 cartridge with an in-between twist. Personal preference would be what dictates that.
Scooter
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