You MIGHT have to swap the magazine as well. Having said that when I swapped an '06 to 338WM I swapped the mag but I found the original worked a little better.

That 280 AI DOES sound like a sweet round. I had a 280 once, but it was an H&R and the safest place to be with that rifle was right in front of the barrel, cause the bullets went everywhere else. Recoil was less than the 110 '06 I have though, at least before my Kick Eze recoil pad install.