I am a big 6mm guy so this is hard to say, but I like the idea above of the 250 Savage, but I would look hard at a 250-AI if you hand loading. Going this route allows you to run up to 120gr bullets if needed and nips right on the heels of the 25-06 and the 243 with similar weight bullets.

I have one in a 16.5" barrel and I am liking it. Brass is simple because you just neck up 22-250 brass. Recoil is minimal, I was first shooting mine in my Striker pistol and I've had 38 SPL's that kicked harder than it did. Accuracy was good. I have not found anything not to like about the 250-AI so far (other than its not one of my favored 6mm bores ) and it adds a little "cool" factor to the wife's rifle for ya.