I have an Alaskan Brush Hunter in 375 Ruger. From my reading, you want to have the longer barrel for Africa as there is only 18 inches of usable barrel in the Brush Hunter and that supposedly costs you performance (like any rifle).

I run a middle of the road 4064 load under 235gr Barnes bullets, but its pretty mild to the factory Hornady ammo from what I've read.

One thing is that its not a widely used caliber, and finding ammunition abroad would be my only concern with taking it to Africa.