The 270 is the one I always recommend to people that ask me what I think is the best all around caliber. It really does everything well and will tackle anything in North America with proper bullet choice and shot placement. Factory ammo is easily found on the shelf just about anywhere and when handloaded the cartridge is even better. I know that berger is working on a heavy 160 grain for the 270 but its not availble yet and I think cutting edge bullets offers a 160 so there is a couple options for the heavier bullets. Personally I dont think it gets any better than a 130 classic hunter from berger at close to 3100 fps. With a bc of .497 only 34 points lower than the 150 this combo is really hard to beat.