Fjold brings up a good point in twist rate. Another thing to think about is what you are going to be shooting at long ranges. If you are punching paper you just need to the bullet to get there and be able to predict the drops. But if you are planning on shooting something like steel silhouettes the 22-250 would get there but might not have enough poop left in it to knock down a steel ram at 500 meters.

Just a thought.