I always suggest the .22-250 for the answer to this question. It will run a 55 grain bullet at 3700+ which is all I have ever been able to get out of either of my .243s with a 55 grain bullet. Besides that the .22 cal 55-60 grain bullet will have a higher bc than the shorter fatter bullet of the .243. This translates into more punch at extended ranges and less wind drift. The .22-250 also solves the problem of not being enough gun for the larger coyotes or the extremly tough ones like we have here in AZ. As far as pelt dmage goes it really all depends on shot placement. Ive had my .223 blow some pretty big holes in both coyotes and bobcats with 55 grain Vmaxs and I have also had them go in and not come out. I think a .22-250 with a match king would probably be the way I would go if I was in the busines of trying to save pelts and get more punch. Just my .02.