grew up in moose territory. perfect shot placement from a .22 will kill a moose, however if you wound one it will return the favour....really. An "honest" 30 cal. is what most "resident" moose hunters seem to use, 30-06, .308, .303 are the most common where I grew up, visiting hunters tend to use $5K exotics of every large caliber known to man... .338 from what I hear is the latest rage.