It might, or might not. Grendel is a wider cartridge than the 223, so you might have to fool with feed lips to feed reliably.
The grendel seems like a good cartridge, but you would get more bang for your buck with 6.5 CM, 6.5x47 lapua, or 260. The grendel will not use all of the action space you have available in a Savage, as it was designed for an AR-15.
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