The 22 WRF is basically the same as a 22LR just longer. The 22 WMR has brass that is a slightly larger diameter so it cannot be chambered in a 22LR. If you put a 22WRF in a 22WMR chamber chances are it would be challenging to extract and the case may split due to being fired in a larger diameter chamber.

If its chambered for one or the other, only fire that ammo in it.